Endocrine Abstracts

Oxidative stress is regarded as a pathogenic factor in hyperthyroidism. IL6 has been described as acting as a protective intrahepatocellular against oxidative stress and mitochondrial dysfunction. On the opposite way leptin has been shown to increase oxidative stress. The impact of thyroid hormones on circulating cytokines levels has been demonstrated with conflicting results both in human and rats. Most of the studies concerned hyperthyroidism showed increased levels of IL6 c...

Obesity leads to low-grade inflammation, and high-fat diet is one of the major causes. On the other hand, menopause can aggravate it by promoting food intake alterations, and metabolic and endocrine adaptations. Thus, we used ovariectomized rats fed with high-fat diet to evaluate changes on the tissue inflammatory state. Forty days-old female Wistar rats were fed with: a hyperlipidic diet enriched with lard – H-group; or chow diet – C-group; for 30 days. After this p...

Many mechanisms are proposed for green tea’s role as anti-obesity and anti-diabetic natural product. Two of them involve the hypothalamic control of energy balance: i) high-fat diets (HFD) rich in saturated fats induce low-grade inflammation, leading to leptin and insulin resistance; ii) serotonin receptors (SR) 1B and 2C activation have anorexigenic effects, SR2C activation improves insulin sensitivity, and HFD can also impair this system. We investigated the effects of ...